Sure, no reason why not!
The best would be a fingering weight worsted spun with a fairly tight twist and tight plying twist. If you are spinning thicker and looser than that, try large eye needles in a 54 or 60 needle cylinder.
Pat Fly has large eye needles available (www.angoravalley.com); I find they help alot with the more fluffy yarns. The thickest yarns I put in my 54 are probably about DK weight or at best a light worsted weight in thickness. And lots of oil to ensure it cranks around okay.
(posted by me this day on sockknittingmachines)